Hormonal regulation of the alpha-ketoglutarate dehydrogenase complex in the isolated perfused rat liver.
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منابع مشابه
The effect of hydrocortisone on tyrosine-alpha-ketoglutarate transaminase and tryptophan pyrrolase activities in the isolated, perfused rat liver.
Administration of hydrocortisone or cortisone to rats has been shown to produce a marked increase in hepatic tryptophan pyrrolase (1, 2) and tyrosine-cY-ketoglutarate transaminase’ (4, 5) activities. Although present evidence suggests that the rise in tryptophan pyrrolase activity involves the synthesis of new protein (6) and the rise in tyrosine transaminase activity may not (7), the mechanism...
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متن کاملStudies on the regulation of the branched chain alpha-keto acid dehydrogenase in the perfused rat liver.
The regulation of the branched chain alpha-keto acid dehydrogenase multienzyme complex was investigated in the isolated, perfused rat liver. The metabolic flux through the branched chain alpha-keto acid dehydrogenase was monitored by measuring the production of 14CO2 from infused 1-14C-labeled branched chain alpha-keto acid substrates. The rate of decarboxylation of alpha-keto[1-14C]isocaproate...
متن کاملThe Regulation of Pyruvate Dehydrogenase in the Isolated Perfused Rat Heart*
The regulation of the pyruvate dehydrogenase multienzyme complex was studied in the isolated perfused rat heart. Because 95% of the “CO2 produced as a result of the decarboxylation of [l-‘4C]pyruvate occurs via pyruvate dehydrogenase in the heart, the rate of 14COz production from infused [l-‘4C]pyruvate was utilized as the monitor of the metabolic flux through this enzyme complex. In contrast ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1988
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)60622-2